I already posted this: http://support.plays.tv/support/discussions/topics/12000002949 a few days ago.
I did some more testing and foud out, that it only happened when I set the encoder to 1080p (any fps, any bitrate)
Here's a short clip: https://youtu.be/vN5t3-um600
happens at 0:03. I moved my mouse like an idiot, but it didnt respond.
Setting the encoding to 720p fixes it.
ticket is already sent.